2019年2月26日佐藤隆博士セミナー

サウスカロライナ医科大学・准教授の佐藤隆博士をお招きしてセミナーを開催致します。2光子カルシウムイメージングや光遺伝学などを駆使してマウス大脳皮質の運動野と視覚野の関係や眼球運動の制御機構、学習のメカニズムについて研究されています。どなたでも参加可能です。ふるってご参加下さい。学部学生・大学院生の参加も歓迎です。

演者: 佐藤 隆 博士

所属: サウスカロライナ医科大学准教授

タイトル: Functional role of reciprocal connections in mouse fronto-parietal cortex

Abstract: Cortical areas are intertwined with networks of reciprocal connectivity. Such connectivity distributes cortical computation across multiple areas. However, the circuit logic underlying the connectivity is unknown. Here we report the basic principle behind how reciprocal connectivity contributes to communication between sensory and motor cortices in mice. Using a newly developed eye movement task, combined with electrical stimulation, anatomical tracing and two-photon calcium imaging, we identified a small area of motor cortex (MOs) that controls eye movements, encoding both motor commands and visual information. We found similar encoding in higher visual areas of the parietal cortex (Vhigh), which reciprocally connected to the MOs. Despite the intermixed signals in the two areas, the information flow between them was selective: motor information was conveyed preferentially from MOs to Vhigh, and sensory information in the opposite direction. We propose that the reciprocal connectivity streamlines information flow, implementing localized processing in the distributed network.

参考文献:
1. Itokazu T et al., (2018) Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task. Nat Comm 9: 338.
2. Hasegawa M et al., (2017) Selective Suppression of Local Circuits during Movement Preparation in the Mouse Motor Cortex. Cell Rep 18: 2676-2686.
3. Niethard N et al., (2016) Sleep-Stage-Specific Regulation of Cortical Excitation and Inhibition. Curr Biol 26:2739-2749.

セミナーは英語ですが、質疑は日本語でも英語でも可能です。

世話人: 医学研究院・疾患情報研究分野 今井 猛