2019年5月9日水野秀信博士セミナー

熊本大学・国際先端医学研究機構(IRCMS)独立准教授の水野秀信博士をお招きしてセミナーを開催致します。マウス体性感覚野をモデルとした、大脳皮質の神経回路発達についてご講演いただきます。ふるってご参加下さい。学部学生・大学院生の参加も歓迎です。

演者: 水野 秀信 博士

所属: 熊本大学・国際先端医学研究機構(IRCMS)

タイトル: In vivo imaging of the developing cerebral cortex to elucidate the mechanisms for activity-dependent circuit formation

日時: 2019年5月9日(木)17:00~18:00
場所: 医学部基礎研究A棟1階 第2講義室(生協向かい)

要旨:  Neuronal activity plays important roles in the establishment of precise neuronal connectivity in the cerebral cortex. Using in vivo two-photon calcium imaging of the mouse somatosensory cortex during the first postnatal week, we previously found that layer 4 cortical neurons fire synchronously, creating a ‘‘patchwork’’ pattern of spontaneous activity corresponding to the barrel map, the cortical correlate of the whisker arrangement. This activity pattern has features suitable for thalamocortical circuit formation in the neonatal somatosensory cortex. In this seminar I would like to discuss the molecular mechanisms regulating the activity pattern generation. Also I would like to introduce preliminary results for elucidating the role of the relationship between micro-level and macro-level phenomena (e.g. dendrite growth and activity correlation, intracellular protein distribution and dendrite patterning) in cortical circuit formation.

参考文献:
1. Nakazawa S, Mizuno H, Iwasato T (2018) Differential dynamics of cortical neuron dendritic trees revealed by long-term in vivo imaging in neonates. Nature communications 9(1) 3106.  
2. Mizuno et al., (2018) Patchwork-Type Spontaneous Activity in Neonatal Barrel Cortex Layer 4 Transmitted via Thalamocortical Projections. Cell Reports 22(1) 123-135 .  
3. Mizuno H et al., (2014) NMDAR-Regulated Dynamics of Layer 4 Neuronal Dendrites during Thalamocortical Reorganization in Neonates. Neuron 82(2) 365-379 .

セミナーは英語ですが、質疑は日本語でも英語でも可能です。

世話人: 医学研究院・疾患情報研究分野 今井 猛