2019年7月16日米原圭祐博士セミナー

デンマーク・トランスレーショナル神経科学研究所(DANDRITE)・北欧EMBL・オーフス大学 グループリーダー/准教授の米原圭祐博士をお招きしてセミナーを開催致します。動体視力をはじめとする視覚系の神経回路についてご講演いただきます。ふるってご参加下さい。学部学生・大学院生の参加も歓迎です。

演者: 米原 圭祐 博士

所属: DANDRITE/Nordic EMBL・オーフス大学

タイトル: Visual motion processing from retina to visual cortical areas in mice

日時: 2019年7月16日(火)17:00~18:00
場所: 医学部基礎研究A棟1階 第2講義室(生協向かい)

Abstract: Inferring the speed and direction of image motion is critical for the survival of animals. Prior studies on rodents and rabbits showed that visual motion processing starts in the retina. However, we are still far from understanding how visual motion is extracted by retinal circuits and further processed in downstream brain areas for mediating visually guided behaviors. Furthermore, it remains unclear how specific neuronal connections that support motion detection emerge during development. To address these questions my lab combines experimental approaches such as molecular biology, transcriptome analysis, mouse genetics, two-photon imaging, electrophysiology, trans-synaptic circuit labeling, behavioral analysis, and computational modeling. In this talk I will present our recent findings related to three topics: 1) how retinal circuits extract the speed and direction of image motion, 2) how cortical areas process retina-originated motion signals, and 3) how motion-sensitive retinal circuits are assembled by molecular mechanisms during development. Our results highlight highly-specific neuronal connections and genetic mechanisms underlying visual motion processing in the mammalian central nervous system.

参考文献:
1. Yonehara K et al., (2016) Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity. Neuron 89: 177-193.  
2. Yonehara K et al., (2013) The first stage of cardinal direction selectivity is localized to the dendrites of retinal ganglion cells. Neuron 79: 1078-1085.  
3. Yonehara K et al., (2011) Spatially asymmetric reorganization of inhibition establishes a motion-sensitive circuit. Nature 469: 407-410.

セミナーは英語ですが、質疑は日本語でも英語でも可能です。

世話人: 医学研究院・疾患情報研究分野 今井 猛