2019年7月30日高橋直矢博士セミナー

ドイツベルリンフンボルト大学Larkum研究室の高橋直矢博士をお招きしてセミナーを開催致します。大脳皮質における樹状突起の情報処理機構と知覚のメカニズムについてご講演いただきます。ふるってご参加下さい。学部学生・大学院生の参加も歓迎です。

演者: 高橋 直矢 博士

所属: ドイツ・ベルリンフンボルト大学

タイトル: Cellular and circuit mechanisms for somatosensory perception

日時: 2019年7月30日(火)17:00~18:00
場所: 医学部基礎研究A棟1階 第2講義室(生協向かい)

Abstract: The result of cortical processing is routed to different downstream targets via distinct pathways – broadly, cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and what cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical dendrites of layer 5 (L5) pyramidal neurons correlates to the threshold for perception (Takahashi et al., 2016). Two distinct classes of L5 neurons target either other cortical areas or subcortical areas. By taking advantage of two transgenic mouse lines, we determined the relative contribution of these L5 subclasses to the perceptual process. We found that the activation of apical dendrites in neurons of the somatosensory cortex that project to subcortical regions almost exclusively determined the detection of whisker deflections in mice. Moreover, dendritic activation was strongly modulated by behavioral context. These results suggest that dendritic activation drives context-dependent interactions between cortex and subcortical regions that are crucial for perception. During the seminar, I will further discuss my long-term goal to develop a mechanistic understanding of how internal brain states, such as attention and expectation, modulate sensory processing to control perceptual behaviors.

参考文献:

Takahashi, N., Oertner, G. T., Hegemann, P. & Larkum, E. M. Active cortical dendrites modulate perception. Science 335, 1587-1590 (2016)
Takahashi, N., Kobayashi, C., Ishikawa, T. & Ikegaya, Y. Subcellular imbalances in synaptic activity. Cell Reports 14: 1348−1354 (2016)
Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N. & Ikegaya, Y. Locally Synchronized Synaptic Inputs. Science 335, 353-356 (2012)
Takahashi, N., Sasaki, T., Matsumoto, W., Matsuki, N. & Ikegaya, Y. Circuit topology for synchronizing neurons in spontaneously active networks. Proceedings of the National Academy of Sciences of the United States of America 107, 10244-9 (2010)

セミナーは英語ですが、一部のみ学生向けに日本語で紹介をしていただきます。質疑は日本語でも英語でも可能です。

世話人: 医学研究院・疾患情報研究分野 今井 猛